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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
1972 1
1973 1
1974 1
1975 11
1976 12
1977 8
1978 15
1979 21
1980 20
1981 32
1982 29
1983 59
1984 57
1985 58
1986 60
1987 67
1988 85
1989 115
1990 111
1991 119
1992 125
1993 127
1994 136
1995 149
1996 143
1997 150
1998 154
1999 178
2000 160
2001 194
2002 217
2003 227
2004 252
2005 289
2006 342
2007 302
2008 312
2009 320
2010 326
2011 327
2012 324
2013 321
2014 327
2015 298
2016 270
2017 258
2018 247
2019 216
2020 242
2021 222
2022 153
2023 109
2024 35

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7,570 results

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Page 1
Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors.
Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y. Kawahara K, et al. Biochim Biophys Acta. 2015 Apr;1851(4):414-21. doi: 10.1016/j.bbalip.2014.07.008. Epub 2014 Jul 17. Biochim Biophys Acta. 2015. PMID: 25038274 Review.
Here, we review the recent advances in PGE2 receptor research by focusing on the activation of mast cells via the EP3 receptor and the control of helper T cells via the EP2/4 receptor, which are the molecular mechanisms involved in PGE2-induced inflammation that had …
Here, we review the recent advances in PGE2 receptor research by focusing on the activation of mast cells via the EP3 receptor and th …
The role of PGE2 and EP receptors on lung's immune and structural cells; possibilities for future asthma therapy.
Cebulla D, van Geffen C, Kolahian S. Cebulla D, et al. Pharmacol Ther. 2023 Jan;241:108313. doi: 10.1016/j.pharmthera.2022.108313. Epub 2022 Nov 24. Pharmacol Ther. 2023. PMID: 36427569 Review.
In this review, we summarize the most important literature on the role of all four E prostanoid (EP) receptors on the lung's immune and structural cells to further dissect the relevance of EP2/EP4 receptors as potential targets for future asthma therapy....
In this review, we summarize the most important literature on the role of all four E prostanoid (EP) receptors on the lung's immune a …
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment.
Gong Z, Li Q, Shi J, Wei J, Li P, Chang CH, Shultz LD, Ren G. Gong Z, et al. Immunity. 2022 Aug 9;55(8):1483-1500.e9. doi: 10.1016/j.immuni.2022.07.001. Epub 2022 Jul 30. Immunity. 2022. PMID: 35908547 Free PMC article.
At steady state, fibroblasts in the lungs produced prostaglandin E2 (PGE2), which drove dysfunctional dendritic cells (DCs) and suppressive monocytes. ...Moreover, the anti-metastatic activity of DC-based therapy and PD-1 blockade was improved by fibroblast-specific Ptgs2 …
At steady state, fibroblasts in the lungs produced prostaglandin E2 (PGE2), which drove dysfunctional dendritic cells (DCs) and suppr …
Emerging roles of PGE2 receptors in models of neurological disease.
Andreasson K. Andreasson K. Prostaglandins Other Lipid Mediat. 2010 Apr;91(3-4):104-12. doi: 10.1016/j.prostaglandins.2009.04.003. Epub 2009 Apr 11. Prostaglandins Other Lipid Mediat. 2010. PMID: 19808012 Free PMC article. Review.
This review presents an overview of the emerging field of prostaglandin signaling in neurological diseases, focusing on PGE(2) signaling through its four E-prostanoid (EP) receptors. A large number of studies have demonstrated a neurotoxic function of the inducible cycloox …
This review presents an overview of the emerging field of prostaglandin signaling in neurological diseases, focusing on PGE(2) signaling thr …
Prostaglandin E receptors.
Sugimoto Y, Narumiya S. Sugimoto Y, et al. J Biol Chem. 2007 Apr 20;282(16):11613-7. doi: 10.1074/jbc.R600038200. Epub 2007 Feb 28. J Biol Chem. 2007. PMID: 17329241 Free article. Review.
Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs responding to PGE(2) designated subtypes EP1, EP2, EP3, and EP4 and multiple splicing isoforms of the subtype EP3. The EP subtypes exhibit differenc …
Prostaglandin (PG) E(2) exerts its actions by acting on a group of G-protein-coupled receptors (GPCRs). There are four GPCRs respondi …
The Roles of EP4 Prostanoid Receptors in Cancer Malignancy Signaling.
Fujino H. Fujino H. Biol Pharm Bull. 2016;39(2):149-55. doi: 10.1248/bpb.b15-00840. Biol Pharm Bull. 2016. PMID: 26830476 Free article. Review.
There are five major prostanoids, including prostaglandin E2 (PGE2), and they are involved in a variety of biological responses such as inflammation, allergy, parturition, and tumorigenesis. These prostanoids exert their effects via activation of their cognate G protein co …
There are five major prostanoids, including prostaglandin E2 (PGE2), and they are involved in a variety of biological responses such …
Effects of PGE2 EP3/EP4 receptors on bladder dysfunction in mice with experimental autoimmune encephalomyelitis.
Xue R, Jia Z, Kong X, Pi G, Ma S, Yang J. Xue R, et al. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1656-62. doi: 10.1152/ajprenal.00271.2013. Epub 2013 Oct 23. Am J Physiol Renal Physiol. 2013. PMID: 24154697 Free article.
Bladders were then harvested for analysis of EP receptor expression by Western blot. Activities of agonists/antagonists of EP3 and EP4 receptors as well as PGE2 were also evaluated at different stages of EAE. ...Moreover, PGE2 and agonists/antagonists of EP3 …
Bladders were then harvested for analysis of EP receptor expression by Western blot. Activities of agonists/antagonists of EP3 and EP4 re …
Platelet prostanoid receptors.
Armstrong RA. Armstrong RA. Pharmacol Ther. 1996;72(3):171-91. doi: 10.1016/s0163-7258(96)00103-9. Pharmacol Ther. 1996. PMID: 9364574 Review.
Prostaglandins (PGs) and thromboxanes are important modulators of platelet activation, and there is strong evidence to support the existence of distinct thromboxane, prostacyclin, PGD2 and PGE2 receptors on the platelet plasma membrane. In this review, each of these …
Prostaglandins (PGs) and thromboxanes are important modulators of platelet activation, and there is strong evidence to support the existence …
EP2 and EP4 receptors mediate PGE2 induced relaxation in murine colonic circular muscle: pharmacological characterization.
Martinez-Cutillas M, Mañé N, Gallego D, Jimenez M, Martin MT. Martinez-Cutillas M, et al. Pharmacol Res. 2014 Dec;90:76-86. doi: 10.1016/j.phrs.2014.10.001. Epub 2014 Oct 20. Pharmacol Res. 2014. PMID: 25461458
The aim of the present work is to pharmacologically characterize responses to exogenous and endogenous PGE2 in the mouse colon targeting EP2 and EP4 receptors. METHODS: Wild type (WT) and EP2 receptor knockout (EP2-KO) mice were used to characterize PGE2 and …
The aim of the present work is to pharmacologically characterize responses to exogenous and endogenous PGE2 in the mouse colon target …
EP2 receptors mediate airway relaxation to substance P, ATP, and PGE2.
Fortner CN, Breyer RM, Paul RJ. Fortner CN, et al. Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L469-74. doi: 10.1152/ajplung.2001.281.2.L469. Am J Physiol Lung Cell Mol Physiol. 2001. PMID: 11435222 Free article.
Using mice homozygous for a gene-targeted deletion of the EP2 receptor [EP2(-/-)], one of the PGE2 receptors, we tested the hypothesis that PGE2 is the primary mediator of relaxation to SP or ATP. ...Taken together, this experimental evidence supports the fol …
Using mice homozygous for a gene-targeted deletion of the EP2 receptor [EP2(-/-)], one of the PGE2 receptors, we tested the hy …
7,570 results